By Donald Huddler,Edward R. Zartler
Applied Biophysics for Drug Discovery is a consultant to new ideas and techniques to determining and characterizing small molecules in early drug discovery. Biophysical tools are reasserting their software in drug discovery and during a mix of the increase of fragment-based drug discovery and an elevated concentrate on extra nuanced characterisation of small molecule binding, those equipment are enjoying an expanding position in discovery campaigns.
This textual content emphasizes useful concerns for choosing and deploying middle biophysical technique, together with yet now not restricted to ITC, SPR, and either ligand-detected and protein-detected NMR.
Topics coated include:
• layout issues in biophysical-based lead screening
• Thermodynamic characterization of protein-compound interactions
• Characterizing objectives and screening reagents with HDX-MS
• Microscale thermophoresis equipment (MST)
• Screening with vulnerable Affinity Chromatography
• easy methods to verify compound place of dwelling time
• 1D-NMR equipment for hit identification
• Protein-based NMR tools for SAR development
• case experiences integrating a number of biophysical methods
This textual content is perfect for tutorial investigators and scientists making plans hit characterization campaigns or designing and optimizing screening strategies.
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Extra info for Applied Biophysics for Drug Discovery
Applied Biophysics for Drug Discovery by Donald Huddler,Edward R. Zartler